PSEUDOMIXOMA PERITONEAL PDF

Department of Radiotherapy, S. Medical College, Agra Address for correspondence: Dr. Medical College, Agra. E-mail: moc.

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Department of Radiotherapy, S. Medical College, Agra Address for correspondence: Dr. Medical College, Agra. E-mail: moc.

This article has been cited by other articles in PMC. Abstract Pseudomyxoma peritonei is a poorly understood and uncommon tumor that is known for its production of mucin in the abdominal cavity and mucinous implants, diffusely involving the peritoneal surfaces.

A year-old female presented to us with post-op complaints of diffuse abdominal pain and distension. On work-up, she was diagnosed as a case of Pseudomyxoma peritonei with residual disease. She received chemotherapy in the form of oral capecitabine for residual disease. She was totally asymptomatic till the last follow-up. This case is being reported on account of its rarity and to emphasize a simple alternative treatment option as compared to the standard one.

Keywords: Oral capecitabine, Pseudomyxoma peritonei INTRODUCTION Pseudomyxoma peritonei, a syndrome first described in , is an enigmatic, often fatal, intra-abdominal disease characterized by disseminated gelatinous ascites and multifocal peritoneal epithelial implants, secreting copious globules of extracellular mucin. Her records were checked and the surgical details revealed that she was operated in view of intestinal obstruction and on exploration of the abdomen, bilateral ovarian cysts were present with an appendicle mass and few gelatinous material on the surface of the appendix.

Therefore, she underwent surgery in the form of right ovarian cyst salpingoopherectomy, left ovarian cyst excision and appendicectomy. Histopathology on gross examination showed gelatinous material within the multiloculated cyst and the appendix. The cut-surface showed dilated appedicular lumen measuring 0. Microscopic examination was suggestive of invasive well-differentiated mucinous adenocarcinoma appendix with features of Pseudomyxoma peritonei and serosal rupture, borderline atypical proliferative mucinous tumor bilateral ovaries and unremarkable right fallopian tube.

Base of the appendix was tumor free. The ovarian tumor probably represents metastatic tumor from the appendicial primary. The margins were well defined and multiple thick septa were seen. Small cysts were also seen in the left ovary. She was properly examined.

On per-abdomen examination, no organomegaly was found; the abdomen was distended, but no shifting dullness or fluid thrill was present. On per-vaginal examination, no significant finding was present No lymphadenopathy was present. She was properly investigated.

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Pseudomixoma peritoneal

Cause[ edit ] The primary tumor appears to arise from the MUC2 expressing goblet cells and most commonly from these cells in the appendix. The K-Ras and p53 genes may be involved in the oncogenesis. It may be diagnosed with a range of conditions. While the majority of these cases are associated with appendiceal carcinomas, [3] other conditions may also be found, including disseminated peritoneal adenomucinosis DPAM , peritoneal carcinomas, several mucinous tumors mucinous adenocarcinoma, mucinous cystadenoma, and mucinous cystadenocarcinoma , as well as other disease states. Diagnosis[ edit ] This disease is often discovered during surgery for other conditions, e. Advanced stages may present as tumors palpable on the abdomen or distention of the belly "jelly belly" is sometimes used as a slang term for the condition.

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